Oral Solution Tablets

HIV infection.

280 LAMIVUDINE

Adults and adolescents, aged 12—16 years: 150 mg b.i.d. in combination with AZT. For adults with low body weight (less than 50 kg), the recommended dose is 2 mg/kg b.i.d. in combination with AZT. Children, 3 months to 12 years of age: 4 mg/kg b.i.d. (up to a maximum of 150 mg b.i.d.) in combination with AZT. In clients over 16 years of age, the dose should be adjusted, as follows, in impaired renal function. Creati-nine clearance (CCR) less than 50 mL/min: 150 mg b.i.d., CCR 30-49 mL/min: 150 mg once daily. CCR 15-29 mL/min: 150 mg for the first dose followed by 100 mg once daily. CCR 5-14 mL/min: 150 mg for the first dose followed by 50 mg once daily. CCR less than 5 mL/min: 50 mg for the first dose followed by 25 mg once daily.

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