Oral Suspension Chewable Tablets

Seizures.

Adults, initial: 100 mg (125 mg of the suspension) t.i.d.; adjust dosage at 7-to 10-day intervals until seizures are controlled; usual, maintenance: 300-400 mg/day, although 600 mg/day (625 mg of the suspension) may be required in some. Pediatric, initial: 5 mg/kg/day in two to three divided doses; maintenance, 4-8 mg/kg (up to maximum of 300 mg/day). Children over 6 years may require up to 300 mg/day. Geriatric: 3 mg/kg initially in divided doses; then, adjust dosage according to serum levels and response. Once dosage level has been established, the extended capsules may be used for once-a-day dosage.

• Capsules, Extended-Release Capsules

Seizures.

Adults, initial: 100 mg t.i.d.; adjust dose at 7- to 10-day intervals until control is achieved. An initial loading dose of 12-15 mg/kg divided into two to three doses over 6 hr followed by 100 mg t.i.d. on subsequent days may be preferred if seizures are frequent. Pediatric: See dose for Oral Suspension and Chew-able Tablets.

Arrhythmias.

B Adults: 200-400 mg/day.

Status epilepticus. Adults, loading dose: 10-15 mg/kg at a rate not to exceed 50 mg/min; then, 100 mg PO or IV q 6-8 hr. Pediatric, loading dose: 15-20 mg/kg in divided doses of 5-10 mg/kg given at a rate of 1-3 mg/kg/min.

Arrhythmias. Adults: 100 mg q 5 min up to maximum of 1 g.

Dose should be 50% greater than the PO dose.

Neurosurgery. 100-200 mg q 4 hr during and after surgery (during first 24 hr, no more than 1,000 mg should be administered; after first day, give maintenance dosage).

0 0

Post a comment