Pirbuterol acetate

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[peer-BYOU-ter-ohl] Pregnancy Category: C

Maxair Autohaler (Rx) Classification: Sympathomimetic, bronchodilator

See also Sympathomimetic Drugs. Action/Kinetics: Causes bronchod-ilation by stimulating beta-2-adren-ergic receptors. Has minimal effects on beta-1 receptors. Also inhibits histamine release from mast cells, causes vasodilation, and increases ciliary motility. Onset, inhalation: Approximately 5 min. Time to peak effect: 30-60 min. Duration: 5 hr. Uses: Alone or with theophylline or steroids, for prophylaxis and treatment of bronchospasm in asthma and other conditions with reversible bronchospasms, including bronchitis, emphysema, bronchiectasis, obstructive pulmonary disease. May be used with or without theophy-lline or steroids.

Contraindications: Cardiac arrhythmias due to tachycardia; tachycardia caused by digitalis toxicity. Special Concerns: Safety and efficacy have not been determined in children less than 12 years of age. Additional Side Effects: CV: PVCs, hypotension. CNS: Hyperactivity, hy-perkinesia, anxiety, confusion, depression, fatigue, syncope. Oral: Bad taste or taste change, stomatitis, glossitis, dry mouth. GI: Diarrhea, anorexia, loss of appetite, abdominal pain, abdominal cramps. Der-matologic: Rash, edema, pruritus, alopecia. Miscellaneous: Flushing, numbness in extremities, weight gain.

How Supplied: Aerosol solid w/adapter: 0.2 mg/inh

Dosage-

• Inhalation Aerosol Adults and children over 12 years: 0.2-0.4 mg (1-2 inhalations) q 4-6 hr, not to exceed 12 inhalations (2.4 mg) daily.

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