Propranolol hydrochloride

[proh-PRAN-oh-lohl] Pregnancy Category: C

Apo-Propranolol M, Detensol M, Dom-Propranolol M, Inderal, Inderal 10, 20, 40, 60, 80, and 90, Inderal LA, Novo-Pranol M, Nu-Propranolol M, PMS Propranolol M, Propranolol In-tensol (Rx)

Classification: Beta-adrenergic blocking agent; antiarrhythmic (type II)_

See also Beta-Adrenergic Blocking Agents.

Action/Kinetics: Manifests both beta-1- and beta-2-adrenergic blocking activity. Antiarrhythmic action is due to both beta-adrenergic receptor blockade and a direct membrane-stabilizing action on the cardiac cell. Has no intrinsic sympathomimetic activity and has high lipid solubility. Onset, PO: 30 min; IV: immediate. Maximum effect: 1-1.5 hr. Duration: 3-5 hr. tV2: 2-3 hr (8-11 hr for long-acting). Therapeutic serum level, antiarrhythmic: 0.05-0.1 mcg/mL. Completely metabolized by liver and excreted in urine. Although food increases bioavailabil-ity, absorption may be decreased.

Uses: Hypertension (alone or in combination with other antihyper-tensive agents). Angina pectoris, hypertrophic subaortic stenosis, prophylaxis of MI, pheochromocytoma, prophylaxis of migraine, essential tremor. Cardiac arrhythmias. Anxiety, aggressive behavior. Contraindications: Hypersensitiv-ity to propranolol, cardiogenic shock, 2nd or 3rd degree heart block, sinus bradycardia, congestive heart failure, cardiac failure. Bronchial asthma, bronchospasms including severe COPD. Special Concerns: Children, diabetes mellitus, hepatic disease, hy-perthyroidism, hypotension, lactation, myasthenia gravis, peripheral vascular disease, renal disease. It is dangerous to use propranolol for pheochromocytoma unless an al-pha-adrenergic blocking agent is already in use.

Side Effects: Oral: Dry mouth. CV: AV block, bradycardia, CHF, hypotension, peripheral vascular insufficiency, vasodilation. CNS: Bizarre dreams, depression, disorientation, fatigue, hallucinations, lethargy, paresthe-sias. GI: Acute pancreatitis, colitis, constipation, cramps, diarrhea, hepa-

Btomegaly, nausea, vomiting. Hematologic: Agranulocytosis, thrombocytopenia. Allergic: Fever, sore throat, respiratory distress, rash, pharyngitis, laryngospasm, anaphylaxis. Skin: Fever, pruritus, rash. Ophthalmic: Dry eyes. GU: Decreased libido, impotence, urinary tract infection. Other: Hypoglycemia. Respiratory: Bron-chospasm, dyspnea, wheezing. Additional Side Effects: Psoriasislike eruptions, skin necrosis, SLE (rare).

Drug Interactions: See also Drug Interactions for Beta-Adrenergic Blocking Agents and Antihyperten-sive Agents.

How Supplied: Capsule, extended release: 60 mg, 80 mg, 120 mg, 160 mg; Concentrate: 80 mg/mL; Injection: 1 mg/mL; Solution: 20 mg/5 mL, 40 mg/5 mL; Tablet: 10 mg, 20 mg, 40 mg, 60 mg, 80 mg

Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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