Ropinirole hydrochloride

[roh-PIN-ih-roll] Pregnancy Category: C Requip (Rx)

Classification: Antiparkinson agent

See also Antiparkinson Agents. Action/Kinetics: Mechanism is not known but believed to involve stimulation of postsynaptic D2 dopamine receptors in caudate-putamen in brain. Causes decreases in both systolic and diastolic BP at doses above 0.25 mg. Rapidly absorbed. Peak plasma levels: 1-2 hr. Food reduces maximum concentration. tV2, elimination: 6 hr. First pass effect; extensively metabolized in liver. Uses: Treat signs and symptoms of id-iopathic Parkinson's disease. Contraindications: Lactation. Special Concerns: Safety and efficacy have not been determined in children.

Side Effects: Oral: Dry mouth. CNS: Hallucinations, cause and/or exacerbate pre-existing dyskinesia. CV: Syncope (sometimes with bradycar-dia), postural hypotension.

Drug Interactions

Ciprofloxacin / Significant T in ro-pinirole plasma levels Estrogens / i Oral clearance of ro-pinirole

How Supplied: Tablets: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 5 mg


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