[lee-voh-thigh-ROX-een] Pregnancy Category: A
See also Thyroid Drugs. Action/Kinetics: Levothyroxine is the synthetic sodium salt of the levoi-somer of T4 (tetraiodothyronine). Le-vothyroxine, 0.05-0.6 mg equals approximately 60 mg (1 grain) of thyroid. Absorption from the GI tract is incomplete and variable, especially when taken with food. Has a slower onset but a longer duration than sodium liothyronine. More active on a weight basis than thyroid. Is usually the drug of choice. Effect is predictable as thyroid content is standard. Time to peak therapeutic effect: 3-4 weeks. tV2: 6-7 days in a euthyroid person, 9-10 days in a hypothy-roid client, and 3-4 days in a hyper-thyroid client. Is 99% protein bound. Duration: 1-3 weeks after withdrawal of chronic therapy. NOTE: All levothyroxine products are not bio-equivalent; thus, changing brands is not recommended. Drug Interactions: Concurrent use of aluminum hydroxide and levothy-roxine may result in adsorption of levothyroxine to the aluminum and increased fecal elimination of levothy-roxine.
How Supplied: Powder for injection: 0.2 mg, 0.5 mg; Tablet: 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.137 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.5 mg
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