Tablets

Parkinsonism. Initial: Start with 0.125 mg t.i.d.; then, increase dose by 0.125 mg t.i.d. weekly for 7 weeks (i.e., dose at week 7 is 1.5 mg t.i.d.). Maintenance: 1.5-4.5 mg/day in equally divided doses t.i.d. with or without co-mcomitant levodopa (about 800 mg/day).

Impaired renal function, CCR, over 60 mL/min: Start with 0.125 mg t.i.d., up to maximum of 1.5 mg t.i.d. CCR, 25-59 mL/min: Start with 0.125 mg b.i.d., up to maximum of 1.5 mg b.i.d. CCR, 15-24 mL/min: Start with

0.125.mg once daily, up to maximum of 1.5 mg once daily.

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