Hypertension. Adult, initial: 10 mg q.i.d for 2-4 days; then, increase to 25 mg q.i.d. for rest of first week. For second and following weeks, increase to 50 mg q.i.d. Maintenance: individualized to lowest effective dose; maximum daily dose should not exceed 300 mg. Pediatric, initial: 0.75 mg/kg/day (25 mg/m2/day) in two to four divided doses; dosage may be increased gradually up to 7.5 mg/kg/day (or 300 mg/day). Food increases the bioavailability of the drug.
• IV, IM Hypertensive crisis.
Adults, usual: 20-40 mg, repeated as necessary. BP may fall within 5-10 min, with maximum response in 10-80 min. Usually switch to PO medication in 1-2 days. Dosage should be decreased in clients with renal damage. Pediatric: 0.1-0.2 mg/kg q 4-6 hr as needed.
Eclampsia. 5-10 mg q 20 min as an IV bolus. If no effect after 20 mg, another drug should be tried.
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