To produce blockade of opiate actions.

Initial: 25 mg followed by an additional 25 mg in 1 hr if no withdraw al symptoms occur. Maintenance: 50 mg/day.

Alternate dosing schedule for blockade of opiate actions. The weekly dose of 350 mg may be given as: (a) 50 mg/day on weekdays and 100 mg on Saturday; (b) 100 mg/48 hr; (c) 100 mg every Monday and Wednesday and 150 mg on Friday; or, (d) 150 mg q 72 hr.

Alcoholism. 50 mg once daily for up to 12 weeks. Treatment for longer than 12 weeks has not been studied.

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