Mild hypothyroidism. Adults, initial: 50 mcg once daily; then, increase by 25-50 mcg q 2-3 weeks until desired clinical response is attained; maintenance, usual: 75-125 mcg/day (although doses up to 200 mcg/day may be required in some clients).
Severe hypothyroidism. Adults, initial: 12.5-25 mcg once daily; then, increase dose, as necessary, in increments of 25 mcg at 2- to 3-week intervals.
Congenital hypothyroidism. Pediatric, 12 years and older: 2-3 mcg/kg once daily until the adult daily dose (usually 150 mcg) is reached. 6-12 years of age: 4-5 mcg/kg/day or 100-150 mcg once daily. 1-5 years of age: 5-6 mcg/kg/day or 75-100 mcg once daily. 6-12 months of age: 6-8 mcg/kg/day or 50-75 mcg once daily. Less than 6 months of age: 8-10 mcg/kg/day or 25-50 mcg once daily. • IM, IV
Myxedematous coma. Adults, initial: 400 mcg by rapid IV injection, even in geriatric clients; then, 100-200 mcg/day, IV. Maintenance: 100-200 mcg/day, IV. Smaller daily doses should be given until client can tolerate PO medication.
Hypothyroidism. Adults: 50-100 mcg once daily; pediatric, IV, IM: A dose of 75% of the usual PO pediatric dose should be given.
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