Tablets Sustained Release Capsules Oral Solution Concentrate

Hypertension. Initial: 40 mg b.i.d. or 80 mg of sustained-release/day; then, increase dose to maintenance level of 120-240 mg/day given in two to three divided doses or 120-160 mg of sustained-release medication once daily. Maximum daily dose should not exceed 640 mg. Pediatric, initial: 0.5 mg/kg b.i.d.; dose may be increased at 3- to 5-day intervals to a maximum of 1 mg/kg b.i.d. The dosage range should be calculated by weight and not by body surface area.

Angina.

Initial: 80-320 mg b.i.d., t.i.d., or q.i.d.; or, 80 mg of sustained-release once daily; then, increase dose gradually to maintenance level of 160 mg/day of sustained-release capsule. The maximum daily dose should not exceed 320 mg.

Arrhythmias. 10-30 mg t.i.d.-q.i.d. given after meals and at bedtime.

Hypertrophic subaortic stenosis. 20-40 mg t.i.d.-q.i.d. before meals and at bedtime or 80-160 mg of sustained-release medication given once daily.

MI prophylaxis. 180-240 mg/day given in three to four divided doses. Total daily dose should not exceed 240 mg.

Pheochromocytoma, preoperatively. 60 mg/day for 3 days before surgery, given concomitantly with an alpha-adrenergic blocking agent.

Inoperable tumors. 30 mg/day in divided doses.

Migraine. Initial: 80 mg sustained-release medication given once daily; then, increase dose gradually to maintenance of 160-240 mg/day in divided doses. If a satisfactory response has not been observed after 4-6 weeks, the drug should be discontinued and withdrawn gradually.

Essential tremor.

Initial: 40 mg b.i.d.; then, 120 mg/day up to a maximum of 320 mg/day.

Aggressive behavior. 80-300 mg/day.

Anxiety. 80-320 mg/day.

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