Psychoses. Adults, initial: 5-10 mg once daily without regard to meals. Goal is 10 mg daily; increments to reach 10 mg can be in 5-mg amounts but at an interval of 1 week. Doses higher than 10 mg daily are recommended only after clinical assessment and should not be greater than 20 mg/day. The recommended initial dose is 5 mg in those who are debilitated, who have a predisposition to hypotensive reactions, who may have factors that cause a slower metabolism of olanzapine (e.g., nonsmoking female clients over 65 years of age), or who may be more sensitive to the drug. It is recommended that clients who respond to the drug be continued on it at the lowest possible dose to maintain remission with periodic evaluation to determine continued need for the drug.

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