Terfenadine

[ter-FEN-ah-deen] Pregnancy Category: C

Apo-Terfenadine M, Novo-Terfena-dine M, Seldane [Rx] Classification: Antihistamine, piperi-dine type

See also Antihistamines. Action/Kinetics: Manifests significantly less drowsiness and anticholi-nergic effects than other antihista-mines. Onset: 1-2 hr; peak effect: 3-4 hr; peak plasma levels: 2 hr. tV2: About 20 hr. Duration: Over 12 hr. Metabolized in the liver and excreted in the urine and feces.

Note: Terfenadine has been withdrawn from the market. Uses: Seasonal allergic rhinitis. Non-FDA Approved Uses: Histamine-in-duced bronchoconstriction in asthmatics; exercise and hyperventila-tion-induced bronchospasm. Contraindications: Significant hepatic dysfunction. Use with drugs that prolong the QT interval, such as disopyramide, procainamide, quini-dine, most antidepressants, and most neuroleptics. Consumption of grapefruit juice.

Special Concerns: Safety and efficacy in children less than 12 years of age have not been established. Hepatic insufficiency and any drug or food (e.g., grapefruit juice) that blocks the metabolism of terfenadine may cause serious CV effects (see Side Effects that follow).

Additional Side Effects: Doses of 360 mg or more may cause serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias (including QT interval prolongation). Syncope may precede severe arrhythmias. Drug Interactions Azole antifungal drugs / T Risk of serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias Clarithromycin / T Risk of serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias Erythromycins / T Risk of serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias Itraconazole / T Risk of serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias Ketoconazole / T Risk of serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias Macrolide antibiotics / T Risk of serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias Sparfloxacin / T Effect of terfena-dine due to l breakdown by the liver.

Troleandomycin / T Risk of serious CV effects, including death, cardiac arrest, torsades de pointes, and other ventricular arrhythmias How Supplied: Tablet: 60 mg

Dosage-

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