Tetracycline hydrochloride

[teh-trah-SYE-kleen] Pregnancy Category: D (topical solution is B)

Achromycin Topical Ointment, Achromycin V, Apo-Tetra M, Jaa Tetra M, Medicycline M, Nor-Tet, Novo-Tetra M, Nu-Tetra M, Panmycin, Robicaps, Sumycin 250 and 500, Sumycin Syrup, Tetracap, Tetracyn M, Topicycline Topical Solution [Rx] Classification: Antibiotic, tetracycline

See also General Information on Tetracyclines.

Action/Kinetics: tV2: 7-11 hr. From 40% to 70% excreted unchanged in urine; 65% bound to serum proteins. Always express dose as the hydro-chloride salt.

Uses: See also General Information on Tetracyclines.

Additional Uses: Ophthalmic:

Superficial ophthalmic infections due to Staphylococcus aureus, Streptococcus, Streptococcus pneumoniae, Escherichia coli, Neisseria, and Bacteroides. Prophylaxis of Neisseria gonorrhoeae in newborns. With oral therapy for treatment of Chlamydia trachomatis. Topical: Acne vulgaris, prophylaxis or treatment of infection following skin abrasions, minor cuts, wounds, or burns. Tetracycline fiber: Adult periodontitis. Non-FDA Approved Uses: Pleural sclerosing agent in malignant pleural effusions (administered by chest tube); in combination with gentamicin for Vibrio vulnificus infections due to wound infection after trauma or by eating contaminated seafood. Mouthwash (use suspension) to treat nonspecific mouth ulcerations, canker sores, aphthous ulcers. Possible drug of choice for stage I Lyme disease.

Contraindications: Use of the topical ointment in or around the eyes. Ophthalmic products to treat fungal diseases of the eye, dendritic keratitis, vaccinia, varicella, mycobacterial eye infections, or following removal of a corneal foreign body. Periodon-tal fibers should be avoided in acutely abscessed periodontal pockets. See also General Information on Tetracyclines.

Special Concerns: Use tetracycline fiber with caution in clients with a history of oral candidiasis. Use of the fiber in chronic abscesses has not been evaluated. Safety and efficacy of the fiber have not been determined in children.

Side Effects: See also General Information on Tetracyclines. Additional Side Effects: Temporary blurring of vision or stinging following administration. Dermatitis and photosensitivity following ophthalmic use. Use of the tetracycline fiber: Oral candidiasis, glossitis, staining of the tongue, severe gingival hyperplasia, minor throat irritation, pain following placement in an abscessed area, throbbing pain, hyper-sensitivity reactions. Drug Interactions: See also General Information on Tetracyclines. How Supplied: Tetracycline: Syrup: 125 mg/5 mL. Tetracycline hydrochloride: Capsule: 100 mg, 250 mg, 500 mg; Ointment: 3%; Ophthalmic ointment: 1%; Solution: 2.2 mg/mL;

Tablet: 250 mg, 500 mg; Periodontal fiber: 12.7 mg/ 23 cm

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