Blz

abacavir, 288 abciximab, 150 Abel, John J., 3 abortifacients, 126 absorption, 10, 11, 46, 47

speed of, 18, 46 accommodation, eye, 98 accumulation, 48, 49, 50, 51

accumulation equilibrium, 48

ACE, see Angiotensin-con-

verting enzyme ACE inhibitors, 118, 124 diuretics and, 158 heart failure treatment, 132

hypertension treatment, 312, 313

myocardial infarction therapy, 310 acebutolol, 94 acetaminophen, 198, 199 biotransformation, 36 common cold treatment, 324, 325 intoxication, 302 migraine treatment, 322 acetazolamide, 162 N-acetyl-cysteine, 302 acetylcholine (ACh), 82, 98, 166, 182

binding to nicotinic receptor, 64

ester hydrolysis, 34, 35 muscle relaxant effects, 184-187

release, 100, 101, 108 synthesis, 100 see alsocholinoceptors acetylcholinesterase (AChE), 100, 182 inhibition, 102 acetylcoenzyme A, 100 acetylcysteine, 324, 325

N-acetylglucosamine, 268 N-acetylmuramyl acid, 268 acetylsalicylic acid (ASA), 198, 199, 200 biotransformation, 34, 35

common cold treatment, 324, 325

migraine treatment, 322 myocardial infarction therapy, 310 platelet aggregation inhibition, 150, 151, 310 acipimox, 156 acrolein, 298 acromegaly, 242, 243 action potential, 136, 182, 186

active principle, 4 acyclovir, 284, 285, 286, 287

acylaminopenicillins, 270 acyltransferases, 38 Addison's disease, 248 adenohypophyseal (AH)

hormones, 242, 243 adenylate cyclase, 66 adrenal cortex (AC), 248

insufficiency, 248 adrenal medulla, nicotinic stimulation, 108, 109, 110

adrenaline, see epineph-rine adrenergic synapse, 82 adrenoceptors, 82, 230 agonists, 84, 86, 182 subtypes, 84 adrenocortical atrophy, 250

adrenocortical suppression, 250 adrenocorticotropic hormone (ACTH), 242, 243, 248, 250, 251 adriamycin, 298 adsorbent powders, 178

adverse drug effects,

70-75 aerosols, 12, 14 affinity, 56

enantioselectivity, 62 agitation, 106 agonists, 60, 61 inverse, 60, 226 partial, 60 agranulocytosis, 72 AIDS treatment, 288-289 ajmaline, 136 akathisia, 238 akinesia, 188 albumin, drug binding, 30 albuterol, 326, 328 alcohol dehydrogenase

(ADH), 44 alcohol elimination, 44 alcuronium, 184 aldosterone, 158, 164, 165, 248, 249 antagonists, 164 deficiency, 314 purgative use and, 172 alendronate, 318 alfuzosin, 90 alkaloids, 4

alkylating cytostatics, 298 allergic reactions, 72-73,

196, 326-327 allopurinol, 298, 316, 317 allosteric antagonism, 60 allosteric synergism, 60 a-blockers, 90 alprostanil, 118 alteplase, 146, 310 Alzheimer's disease, 102 amantadine, 188, 286, 287 amikacin, 278, 280 amiloride, 164, 165 6-amino-penicillanic acid, 268

y-aminobutyric acid, see GABA

e-aminocaproic acid, 146 aminoglycosides, 267, 276-279

p-aminomethylbenzoic acid (PAMBA), 146 aminopterin, 298 aminopyrine, 198 aminoquinuride, 258 5-aminosalicylic acid, 272 p-aminosalicylic acid, 280 amiodarone, 136 amitriptyline, 230, 232, 233

amodiaquine, 294 amorolfine, 282 amoxicillin, 168, 270, 271 cAMP, 66, 150 amphetamines, 88, 89, 230

see also specific drugs amphotericin B, 282, 283 ampicillin, 270 ampules, 12

amrinone, 118, 128, 132 anabolic steroids, 252 analgesics, 194-203 antipyretic, 4, 196-199, 202-203, 324 see also opioids anaphylactic reactions, 72, 73, 152

treatment, 84, 326, 327 ancrod, 146, 147 Ancylostoma duodenale, 292

androgens, 252 anemia, 138-141, 192 megaloblastic, 192 pernicious, 138 anesthesia balanced, 216, 217 conduction, 204 dissociative, 220 infiltration, 90, 204 premedication, 104, 106, 226

regional, 216 spinal, 204, 216 surface, 204

total intravenous (TIVA), 216

see also general anesthetics; local anesthetics angina pectoris, 128, 306-308, 311, 312 prophylaxis, 308, 311

treatment, 92, 118, 120, 122, 308, 311 angiotensin II, 118, 124, 158, 248 antagonists, 124 biotransformation, 34, 35

formation, 34 angiotensin-converting enzyme (ACE), 34, 124, 158

see also ACE inhibitors angiotensinase, 34 Anopheles mosquitoes, 294

anorexiants, 88 antacids, 166-168 antagonists, 60, 61 anthraquinone derivatives,

170, 174, 176, 177 antiadrenergics, 95-96, 128

antianemics, 138-141 antiarrhythmics, 134-137 electrophysiological actions, 136, 137 antibacterial drugs, 266-282

cell wall synthesis inhibitors, 268-271 DNA function inhibitors,

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