All antiplatelet drugs increase the risk of bleeding. Even at the low ASA doses used to inhibit platelet function (100 mg/d), ulcerogenic and bronchocon-strictor (aspirin asthma) effects may occur. Ticlopidine frequently causes diarrhea and, more rarely, leukopenia, necessitating cessation of treatment. Clo-pidogrel reportedly does not cause he-matological problems.
As peptides, hirudin and abciximab need to be injected; therefore their use is restricted to intensive-care settings.
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