D

daclizumab, 300 dantrolene, 182 dapsone, 272, 280, 281, 294

daunorubicin, 298 dealkylations, 36 deamination, 36 decarbaminoylation, 102 decongestants, 90 deferoxamine, 302, 303 dehalogenation, 36 delavirdine, 288 delirium tremens, 236 dementia, 102 N-demethyldiazepam, 228 demulcents, 178 deoxyribonucleic acid (DNA), 274

synthesis inhibition, 298, 299 dependence benzodiazepines, 223, 226, 228

hypnotics, 222, 223 laxatives, 172, 173 opioids, 210-212 dephosphorylation, 102 depolarizing muscle relaxants, 184, 186, 187 deprenyl, 88 depression, 226, 230 endogenous, 230-233 manic-depressive illness, 230

treatment, 88, 230-233 dermatologic agents, 16, 17

as drug vehicles, 16, 17 dermatophytes, 282 descending antinocicep-

tive system, 194 desensitization, 66 desflurane, 218 desipramine, 230, 232, 233 desmopressin, 164, 165 desogestrel, 254 desulfuration, 36, 37 dexamethasone, 192, 248,

249, 330 dexazosin, 90 dexetimide, 62, 63

dextran, 152 diabetes mellitus hypoglycemia, 92 insulin replacement therapy, 258 insulin-dependent, 260-261

non-insulin-dependent, 262-264 diacylglycerol, 66 diarrhea, 178 antidiarrheals, 178-179 chologenic, 172 diastereomers, 62 diazepam, 128, 228 diazoxide, 118, 312 dicationic, 268 diclofenac, 200, 320 dicloxacillin, 270 didanosine, 288 diethlystilbestrol, 74 diethylether, 216 diffusion barrier to, 20 membrane permeation, 26, 27 digitalis, 130, 131, 302 digitoxin, 132

enterohepatic cycle, 38 digoxin, 132 dihydralazine, 118, 312 dihydroergotamine, 126, 322

dihydropyridines, 122, 308 dihydrotestosterone, 252 diltiazem, 122, 136, 308 dimenhydrinate, 114 dimercaprol, 302, 303 dimercaptopropanesulfon-

ic acid, 302, 303 dimethicone, 180, 181 dimethisterone, 254 2,5-dimethoxy-4-ethyl amphetamine, 240 3,4-dimethoxyampheta-

mine, 240 dimetindene, 114 dinoprost, 126 dinoprostone, 126 diphenhydramine, 114,

222, 230 diphenolmethane derivatives, 170, 174, 177

diphenoxylate, 178 dipole-dipole interaction, 58

dipole-ion interaction, 58 dipyridamole, 150 dipyrone, 198, 199 disinfectants, 290, 291 disintegration, of tablets and capsules, 10 disopyramide, 136 disorientation, atropine poisoning and, 106 Disse's spaces, 24, 32, 33 dissolution, of tablets and capsules, 9, 10 distribution, 22-31, 46, 47 diuretics, 158-165, 313 indications for, 158 loop, 162, 163 osmotic, 160, 161 potassium-sparing, 164, 165

sulfonamide type, 162, 163

thiazide, 132, 162, 163, 312

dobutamine, enantioselec-

tivity, 62 docetaxel, 296 docosahexaenoate, 156 domperidone, 322, 330 L-dopa, 114, 188 DOPA-decarboxylase, 188 dopamine, 88, 114, 115, 132

agonists, 242 antagonists, 114 in norepinephrine synthesis, 82 mimetics, 114 Parkinson's disease and, 188

dopamine receptors, 114, 322

agonists, 188 blockade, 236, 238 dopamine-p-hydroxylase, 82

doping, 88, 89 dorzolamide, 162 dosage forms, 8 dosage schedule, 50, 51 dose-linear kinetics, 68, 69

dose-response relationship, 52-53 dosing irregular, 48, 49 overdosing, 70, 71 repeated, 48, 49 subliminal, 52 double-blind trials, 76 doxorubicin, 298 doxycycline, 277, 278, 294 doxylamine, 22 dromotropism, negative, 134

dronabinol, 330 droperidol, 216, 236 drops, 8, 9

drug interactions, 30, 32

anticonvulsants, 192 drug-receptor interaction,

58-69 drugs active principle, 4 administration, 8-19 adverse effects, 70-75 approval process, 6 barriers to, 22-27 biotransformation, 32, 34-39

concentration time course, 46-47, 48-49, 68, 69

development, 6-7 distribution in body, 22-31, 46, 47 liberation of, 10 protein binding, 30-31 retarded release, 10, 11 sites of action, 20-21 sources, 4

see alsoelimination of drugs; specifictypes ofdrugs duodenal ulcers, 104, 166 dusting powders, 16 dynorphins, 210 dyskinesia, 238 dysmenorrhea, 196 dystonia, 238

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