Dna

Building blocks Purines

Inhibition of nucleotide synthesis

Thymine Nucleotide

Tetrahydro-folate

Dihydrofolate Reductase

Folic acid

Dihydrofolate Reductase

Folic acid

Inhibition by

Inhibition by

Insertion of incorrect building blocks

Purine antimetabolite 6-Mercaptopurine from Azathioprine

Pyrimidine antimetabolite 5-Fluorouracil Cytarabine Cytosine Arabinose instead of Adenine instead of Uracil

Cytosine instead of Desoxyribose

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