Drugs for Treating Mycobacterial Infections

Mycobacteria are responsible for two diseases: tuberculosis, mostly caused by M. tuberculosis, and leprosy due to M. le-prae. The therapeutic principle applicable to both is combined treatment with two or more drugs. Combination therapy prevents the emergence of resistant mycobacteria. Because the antibacterial effects of the individual substances are additive, correspondingly smaller doses are sufficient. Therefore, the risk of individual adverse effects is lowered. Most drugs are active against only one of the two diseases.

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