Muscle Relaxants

Muscle relaxants cause a flaccid paralysis of skeletal musculature by binding to motor endplate cholinoceptors, thus blocking neuromuscular transmission (p. 182). According to whether receptor occupancy leads to a blockade or an excitation of the endplate, one distinguishes nondepolarizing from depolarizing muscle relaxants (p. 186). As adjuncts to general anesthetics, muscle relaxants help to ensure that surgical procedures are not disturbed by muscle contractions of the patient (p. 216).

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