The antiandrogen cyproterone

acts as a competitive antagonist of T. In addition, it has progestin activity whereby it inhibits gonadotropin secretion (p. 254). Indications: in men, inhibition of sex drive in hypersexuality; prostatic cancer. In women: treatment of virilization, with potential utilization of the gestagenic contraceptive effect.

Flutamide, an androgen receptor antagonist possessing a different chemical structure, lacks progestin activity.

Finasteride inhibits 5a-reductase, the enzyme converting T. into dihydro-testosterone (DHT). Thus, the androgen-ic stimulus is reduced in those tissues in which DHT is the active species (e.g., prostate). T.-dependent tissues or functions are not or hardly affected (e.g., skeletal muscle, negative feedback inhibition of gonadotropin secretion, and libido). Finasteride can be used in benign prostate hyperplasia to shrink the gland and, possibly, to improve micturition.

-propionate C - C -heptanoate 2 C - C - C - C - C - c| I |> Duration of effect 2 weeks

Testosterone rH'

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