Peripheral Nerve Injury Produces an Increased Expression of Clusterin in Perineuronal Astrocytes

Concomitantly with the response of axotomized motoneurons, astrocytes in their immediate surrounding undergo hypertrophy and express several molecular features of increased activity.1 A structural modification which may be of particular significance for the forthcoming discussion is an increased astrocytic coverage of the axotomized perikarya. This process is probably the consequence of an extensive stripping of presynaptic terminals from the surface of the injured nerve cell bodies, perhaps...

References

1.Wisniewski T, Ghiso J, Frangione B. Biology of Ap amyloid in Alzheimer's disease. Neurobiol Dis 1997 4 311-28. 2. Kalaria RN, Premkumar 6RD, Pax AB et al. Production and increased detection of amyloid p protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease. Mol Brain Res 1996 35 58-68. 3. Haass C, Selkoe DJ. Cellular processing of p-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 1994 75 1039-42. 4....

Peripheral Nerve Injury Produces an Increased Expression of Clusterin in CNS Neuronal Perikarya

The prototypic experimental model for exploring the neuron-glial responses following axon injury is the motoneuron nuclei of cranial or spinal nerves. Shortly after axotomy, the neurons express many features of dedifferentiation, downregulating functions associated with synaptic transmission and upregulating growth-associated processes.1,2 These modifications are believed to enhance regrowth of the injured axons. Motoneurons already express low levels of immunoreactivity for clusterin from...