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The 99th Congress went on to define the meaning of the term "controlled substance analogue" as a substance:

(i) the chemical structure of which is substantially similar to the chemical structure of a controlled substance in schedule I or II;

(ii) which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substantially similar to or greater than the stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II; or

(iii) with respect to a particular person, which person represents or intends to have a stimulant, depressant, or hallucinogenic effect on the central nervous system of a controlled substance in schedule I or II."

The Act goes on to exclude:

(i) a controlled substance

(ii) any substance for which there is an approved new drug application

(iii) with respect to a particular person any substance, if an exemption is in effect for investigational use, for that person, under section 505...to the extent conduct with respect to such substance is pursuant to such exemption; or

(iv) any substance to the extent not intended for human consumption before such an exemption takes effect with respect to that substance.

Treatment of exhibits falling under the purview of the federal court system is described in Public Law 91-513 or Part 1308 of the Code of Federal Regulations. Questions relating to controlled substance analogues and homologues can usually be answered by reference to the Controlled Substances Analogue and Enforcement Act of 1986.

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