Table Of Contents

1 Criminalistics—Introduction to Controlled Substances Joseph P. Bono

2 Pathology of Drug Abuse Edited by Charles V. Wetli

2.1 Preliminary Observations Charles V. Wetli

2.2 Diseases of the Heart

2.2.1 Techniques for Examination of the Heart Renu Virmani, Allen P. Burke, and Andrew Farb

2.2.2 Myocardial Alterations in Drug Abusers Steven B. Karch

2.2.3 Endocarditis Michael D. Bell

2.2.4 Vascular Effects of Substance Abuse Frank D. Kolodgie, Allen Burke, Jagat Narula, Florabel G. Mullick, and Renu Virmani

2.3 Lung Disease Michael D. Bell

2.4 Disorders of the Central Nervous System Michael D. Bell

2.5 Miscellaneous Complications Charles V. Wetli

3 Pharmacokinetics: Drug Absorption, Distribution, and Elimination

Amanda J. Jenkins, and Edward J. Cone

4 Pharmacodynamics Edited by Stephen J. Heishman

4.1 Effects of Abused Drugs on Human Performance: Laboratory Assessment Stephen J. Heishman

4.2 Performance Measures of Behavioral Impairment in Applied Settings Thomas H. Kelly, Richard C. Taylor, Stephen J. Heishman, and Dennis J. Crouch

4.3 Effects of Abused Drugs on Pupillary Size and the Light Reflex Wallace B. Pickworth, Reginald V. Fant, and Edward B. Bunker

4.4 Evaluating Abuse Liability: Methods and Predictive Value Kenzie L. Preston, and Sharon L. Walsh

5 Alcohol Edited by Christopher S. Martin

5.1 Measuring Acute Alcohol Impairment Christopher S. Martin

5.2 Measuring Blood-Alcohol Cencentration for Clinical and Forensic Purposes A. Wayne Jones and Derrick J. Pounder

5.3 Measuring Alcohol Postmortem Derrick J. Pounder and A. Wayne Jones

5.4 Biochemical Tests for Acute and Chronic Alcohol Ingestion Anders Helander and Alan Wayne Jones

6 Neurochemistry of Drug Abuse Edited by Deborah C. Mash and Julie K. Staley

6.1 The Dopamine Transporter and Addiction John W. Boja and William M. Meil

6.2 Neuropsychiatric Consequences of Chronic Cocaine Abuse Deborah C. Mash

6.3 Neurochemical Adaptations and Cocaine Dependence Julie K. Staley

6.4 The Neurobiology of Relapse David W. Self

6.5 Serotonergic Dysfunction During Cocaine Withdrawal: Implications for Cocaine-Induced Depression Michael H. Baumann and

Richard B. Rothman

6.6 Neurochemistry of Psychedelic Drugs J.C. Callaway and D.J. McKenna

7 Addiction Medicine Edited by Kim Wolff

7.1 The Principles of Addiction Medicine Duncan Raistrick

7.2 Substitute Prescribing Kim Wolff

7.2.1.6 Buprenorphine Maintenance Prescribing Douglas Fraser

7.3 Treatment of Withdrawal Syndromes Joanna Banbery

7.4 Replacement Prescribing Kim Wolff

7.4.1 Opiate Specific Prescribing Douglas Fraser

7.5 Management of Comorbidity Duncan Raistrick

7.6 Toxicologic Issues Alastair W.M. Hay

8 Medical Complications of Drug Abuse Edited by Neal L. Benowitz

8.1 Drug-Related Syndromes Shoshana Zevin and Neal L. Benowitz

8.2 Emergency Management of Drug Abuse-Related Disorders Brett A. Roth, Neal L. Benowitz, and Kent R. Olson

9 Sports Edited by Jordi Segura

9.1 Introduction Jordi Segura

9.2 Specific Agents Rafael de la Torre

9.3 Anabolic Androgenic Steroids Don H. Catlin

9.4 Detection of Exogenous Anabolic Androgenic Steroids Wilhelm Schänzer

9.5 Growth Hormone Abuse in Elite Athletes Ross C. Cuneo, Jennifer D. Wallace, and Peter Sönksen

9.6 Erythropoietin Björn Ekblom

9.7 Summary of International Olympic Committee Regulations Jordi Segura

10 Workplace Testing Edited by Yale H. Caplan

10.1 Development and Scope of Regulated Testing J. Michael Walsh

10.2 Laboratory Accreditation Programs

10.2.1 An Overview of the Mandatory Guidelines for Federal Workplace Drug Testing Programs Donna M. Bush

10.2.2 The College of American Pathologists Voluntary Laboratory Accreditation Program John Baenziger

10.3 Analytical Considerations and Approaches for Drugs Michael Peat and Alan E. Davis

10.4 Urine Specimen Suitability for Drug Testing Ruth E. Winecker and Bruce A. Goldberger

10.5 The Role of the Medical Review Officer: Current Issues Steven St. Clair

10.6 Alternative Drugs, Specimens, and Approaches for Non-Regulated Drug Testing Dennis Crouch

10.7 Implementation of Alcohol Testing: General Considerations and Processes Donna R. Smith

11 Alternative Testing Matrices Marilyn A. Huestis and Edward J. Cone

12 Postmortem Toxicology Edited by Wm. Lee Hearn

12.1 Introduction of Postmortem Toxicology Wm. Lee Hearn and H. Chip Walls

12.2 Specimen Selection, Collection, Preservation, and Security Bradford R. Hepler and Daniel S. Isenschmid

12.3 Common Methods in Postmortem Toxicology Wm. Lee Hearn and H. Chip Walls

12.4 Strategies for Postmortem Toxicology Investigation Wm. Lee HHearn and H. Chip Walls

12.5 Quality Assurance in Postmortem Toxicology Wilmo Andollo

12.6 Interpretation of Postmortem Drug Levels Graham R. Jones

13 Drug Law

13.1 Current Legal Issues of Workplace Drug Testing Theodore F. Shults

13.2 DUI Defenses Alan Wayne Jones and Barry Logan

13.3 Fetal Rights Stephen M. Mohaupt

Appendices

Ia Glossary of Terms in Forensic Toxicology Chip Walls Ib Common Abbreviations Chip Walls Ic References for Methods of Drug Quantitative Analysis

II Sample Calculations Barry K. Logan and Alan Wayne Jones

III Predicted Normal Heart Weight (g) as a Function of Body Height

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