Attention Deficit Hyperactivity Disorder

K E Browman and G B Fox, Abbott Laboratories, Abbott Park, IL, USA © 2007 Elsevier Ltd. All Rights Reserved.

6.05.1 Introduction 117

6.05.2 Disease State 118

6.05.3 Disease Basis 120

6.05.4 Experimental Disease Models 120

6.05.4.1 General Considerations for Modeling Attention Defect Hyperactivity Disorder 120

6.05.4.1.1 Diverse clinical symptoms with unknown etiology 120

6.05.4.1.2 Choosing behavioral assays 121

6.05.4.2 Animal Models of Attention Deficit Hyperactivity Disorder 121

6.05.4.2.1 The spontaneously hypertensive rat (SHR) 121

6.05.4.2.2 Dopamine transporter (DAT) knockout mouse 123

6.05.4.2.3 Synaptosome-associated protein of 25kDa (SNAP-25, coloboma mutant) 125

6.05.4.2.4 6-Hydroxydopamine (6-OHDA) lesions 125

6.05.4.3 Other Models 127

6.05.4.3.1 Dorsal prefrontal cortex (dPFC) lesions 127

6.05.4.3.2 Environmental toxins 128

6.05.4.3.3 Neonatal hypoxia 128

6.05.4.3.4 Animals selected for inattention and impulsivity 128

6.05.4.4 Summary 128

6.05.5 Clinical Trial Issues 128

6.05.6 Overview and Comparison of Drug Classes 129

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