Figure 10 Structures of NCEs for novel targets to treat renal dysfunction.

pressure in several models of hypertension including chronic AT-II, DOCA-salt, and Dahl salt-sensitive rats and in saltsensitive stroke-prone spontaneous hypertensive rats.78

In diabetic models, SOD mimetics may play a role in improving endothelial dysfunction. For example, tempol (Figure 10), improves insulin sensitivity and decreases oxidative stress in obese Zucker rats as a model of type 2 diabetes.79 Tempol also reduces oxidative stress and improves endothelial dysfunction in streptozotocin-induced type 1 diabetic rats.80 NADPH oxidase is the main source of superoxide production following AT-II stimulation and mice lacking the p47phox subunit of NADPH oxidase have an attenuated hypertensive response to chronic AT-II infusion.81 Mice lacking the gp91phox subunit also have an attenuated hemodynamic response to acute AT-II.82 Thus, inhibition of NADPH oxidase may be a novel approach to improve endothelial function and lower blood pressure in hypertension.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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