Figure 10 Structures of NCEs for novel targets to treat renal dysfunction.

pressure in several models of hypertension including chronic AT-II, DOCA-salt, and Dahl salt-sensitive rats and in saltsensitive stroke-prone spontaneous hypertensive rats.78

In diabetic models, SOD mimetics may play a role in improving endothelial dysfunction. For example, tempol (Figure 10), improves insulin sensitivity and decreases oxidative stress in obese Zucker rats as a model of type 2 diabetes.79 Tempol also reduces oxidative stress and improves endothelial dysfunction in streptozotocin-induced type 1 diabetic rats.80 NADPH oxidase is the main source of superoxide production following AT-II stimulation and mice lacking the p47phox subunit of NADPH oxidase have an attenuated hypertensive response to chronic AT-II infusion.81 Mice lacking the gp91phox subunit also have an attenuated hemodynamic response to acute AT-II.82 Thus, inhibition of NADPH oxidase may be a novel approach to improve endothelial function and lower blood pressure in hypertension.

Delicious Diabetic Recipes

Delicious Diabetic Recipes

This brilliant guide will teach you how to cook all those delicious recipes for people who have diabetes.

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