Background

Bone serves multiple functions in the body. It provides a strong and rigid frame to enable movement and to support and protect the soft tissues, and it provides a readily accessible store of calcium and phosphorus. To fulfill these complex and at times conflicting roles, bone is a dynamic structure undergoing continual remodeling in response to mechanical stress, damage, and physiological requirements for calcium and phosphorus. Metabolic bone diseases, through their impact on remodeling processes, can impair skeletal function, resulting in bone fractures and disturbances in calcium and phosphorus homeostasis. Significant advances have been made in developing therapies that address underlying disease processes affecting bone, but considerable unmet medical need remains due to the enormous size of affected populations and the limited efficacy and patient acceptance of current treatments.

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