Benzodiazepines

The origin of BZs stemmed from the 'diversity oriented,'81 search for a new tranquilizer. Chlordiazepoxide was synthesized in 1955 but was not evaluated in vivo until 3 years later when it was found to be a potent CNS depressant. The reason for not subjecting chlordiazepoxide to biological evaluation earlier was the fact that the compound was thought to be quinazoline-N-oxide 1, which resulted from the failed synthesis of heptoxdiazine 2 (Figure 2a). Several analogs of 1 were subjected to in vivo evaluation and all failed to show the desired effect. The attempted synthesis of 2 was performed simply because the compounds would be diverse relative to the known tranquilizers of the day

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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