Biomarkers for Neuroprotective Drug Evaluation

A key need to improve the translation of preclinical neuroprotective effects into successful mechanism-based clinical trials is the identification of measurable biomarkers that allow the pathophysiology and drug effects thereon to be determined. Three examples of promising CNS injury biomarkers are the LP-related isoprostanes30 and neuroprostanes,31 calpain and caspase-3-mediated degradation products of the cytoskeletal protein a-spectrin,32 and the astrocytic injury marker S100p.33'34 The validation of these for the monitoring of postischemic or posttraumatic injury is ongoing in multiple centers and should lead to a quantifiable means for the more efficient clinical evaluation of neuroprotective pharmacotherapies with regard to neuroprotective efficacy, dose-response, therapeutic window, and optimal dosing regimen determinations.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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