C02c2h5 C02g2h5

c02ch2ch(ch3)2

c02ch20c0(ch2)2ch3

co2ch5

co2ch2ch=chc6h5

Advantages

CI CI CH3

CI CI CH3

First in class

Vasoselective

Vasoselective Improves cognition?

Vasoselective

Water-soluble Neuroprotective?

Also blocks T channels Has active metabolite

Ultrashort-acting Water-soluble

Vasoselective Antiathrosclerotic

Enhances NO

Dilates veins

Also blocks Na channels

Lercanidipine C02CH3

c02c(ch3)2ch2n(ch2)2ch(ph)2 C02(CH2)2NPhCH2Ph

Benidipine C02CH3

Nimodipine C02CH(CH3)2

CO, n ch2ph

C02(CH2)20CH3

Amlodipine C02CH3

co2c2h5

GFR, glomerular filtration rate; SAH, subarachnoid hemorrhage.

Highly lipophilic

Causes no reflex tachycardia

Also blocks T-channels

Diuretic Increases GFR

Diuretic Increases GFR Antiapoptotic

Neuroprotective Reduces neurological deficits in SAH

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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