C02c2h5 C02g2h5

c02ch2ch(ch3)2

c02ch20c0(ch2)2ch3

co2ch5

co2ch2ch=chc6h5

Advantages

CI CI CH3

CI CI CH3

First in class

Vasoselective

Vasoselective Improves cognition?

Vasoselective

Water-soluble Neuroprotective?

Also blocks T channels Has active metabolite

Ultrashort-acting Water-soluble

Vasoselective Antiathrosclerotic

Enhances NO

Dilates veins

Also blocks Na channels

Lercanidipine C02CH3

c02c(ch3)2ch2n(ch2)2ch(ph)2 C02(CH2)2NPhCH2Ph

Benidipine C02CH3

Nimodipine C02CH(CH3)2

CO, n ch2ph

C02(CH2)20CH3

Amlodipine C02CH3

co2c2h5

GFR, glomerular filtration rate; SAH, subarachnoid hemorrhage.

Highly lipophilic

Causes no reflex tachycardia

Also blocks T-channels

Diuretic Increases GFR

Diuretic Increases GFR Antiapoptotic

Neuroprotective Reduces neurological deficits in SAH

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