8 Darifenacin

Tricyclic antidepressants, particularly imipramine, can also be used for treatment, facilitating urine storage, by both decreasing bladder contractility and by increasing outlet resistance. The 5HT/NE uptake inhibitor (SNRI) duloxetine (9) increases extracellular monoamine levels leading to contraction of the urethral sphincter to prevent urine leakage. Bethanechol (11) is another cholinergic agent used to treat bladder (detrusor) underactivity in individuals with incomplete bladder emptying.

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