Catechol Omethyltransferase inhibitors

An increase in the functional monoamines NE, DA, and 5HT can precipitate mania or rapid-cycling in an estimated 20-30% of affectively ill patients. A strong association between velo-cardio-facial syndrome (VCFS) patients diagnosed with rapid-cycling bipolar disorder, and an allele encoding the low enzyme activity catechol-O-methyltransferase variant (COMT L) has been identified.43 Between 85% and 90% of VCFS patients are hemizygous for COMT. There is nearly an equal distribution of L and H alleles in Caucasians. Individuals with low-activity allele (COMT LL) would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of NE and DA. COMT inhibitors (entacapone (40) and tolcapone (41)) could therefore be beneficial as adjuncts to L-dopa not only in Parkinson's disease but also in the coincident depressive illness associated with rapid cycling.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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