Cimoxatone 21

Ladostigil 22

Isozyme-selective and partly reversible MAOIs have been developed over the last two decades and are described as reversible inhibitors of monoamine oxidase type A (RIMAs). In contrast to the irreversible nonselective inhibitors, selective RIMAs are isozyme selective — MAO-A or MAO-B. MAO-A inhibition results in increases in NE, 5HT, and DA in the synaptic cleft, while selective MAO-B inhibitors increase only DA. The molecular action mechanism of the

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