DA-containing neurons in the VTA that target areas in the limbic region of the brain, especially the NAc and frontal region of the cerebral cortex ( ). In addition, upon chronic drug use leading to addiction, the neuro transmitters involved in regulation of the VTA DA neurons are also affected. As such, glutamatergic receptors, both ionotropic and metabotropic, GABAergic, cholinergic, serotonergic, and noradrenergic input can all be altered.18 Another factor that impacts addictive behavior in humans is drug-induced damage to cortical regions, which normally control executive functions such as decision-making and judgment.19'20

A Disquistion On The Evils Of Using Tobacco

A Disquistion On The Evils Of Using Tobacco

Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.

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