Chronic Models in Higher Species

In contrast to rodents, animals such as rabbits, who naturally express high CETP activity, are spontaneously susceptible to diet-induced atherosclerosis. Rabbit models of atherosclerosis have been used to define the long-term quantitative efficacy of experimental drug products on lesion progression under more chronic conditions. These models typically require dosing up to 6 months or longer. Transgenic rabbit models have also confirmed the contributions that various gene products make to disease progression in rabbits, including apolipoproteins (apo(a), apoA-I, apoB, apoE), hepatic lipase (HL), LCAT, LpL, and 15-LO.33 Primate models of atherosclerosis have also been employed to define the long-term efficacy of experimental drugs for up to 1 year of dosing.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment