Clinical efficacy of hydroxymethylglutarylcoenzyme A reductase inhibitors statins as lowdensity lipoprotein cholesterollowering agents in patients with coronary heart disease

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Statins represent a class of drugs that specifically inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, an enzyme that catalyzes the rate-controlling step in de novo cholesterol biosynthesis.34 Two general classes of statin have been identified: the earlier natural product-based statins (mevastatin 1, lovastatin 2, simvastatin 3, pravastatin 4; Figure 7) and the more recent new generation of synthetic statins (atorvastatin 6, fluvastatin 5, cerivastatin 7, rosuvastatin 8, pitavastatin 9; Figure 7). Since their initial discovery in the mid-1970s, multiple statins have been

The reaction catalyzed by HMG-CoA reductase:

CO2-

CO2-

O SCoA

HMG-CoA

CO2-OH SCoA

co2-

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