Clinical Trial Issues

In the early 1980s several pharmaceutical companies became attracted to the idea of discovering neuroprotective drugs for the acute treatment of stroke and CNS injury. As a result, several new compound entities were discovered that were entered into development, with some making their way into large double-blind, multicenter, phase III clinical trials for stroke (ischemic and SAH), TBI, and/or SCI. These efforts, which dominated neuroprotective clinical trials in the 1980s and 1990s, were primarily directed at three general pharmacological mechanistic strategies to interrupt secondary injury processes:

1. inhibition of glutamate-mediated excitotoxicity (i.e., glutamate receptor antagonists; GABA agonists)

2. reduction of intracellular calcium overload (L-type calcium channel blockers)

3. interruption of reactive-oxygen-mediated damage (i.e., free radical scavengers/antioxidants).

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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