Clinical use

The clinical efficacy of glitinides is similar to that of the sulfonylureas. In short-term, placebo-controlled trials, repaglinide monotherapy reduced HbA1C levels from 8.5% at baseline to 7.8% after only 12 weeks. In individuals with T2DM not previously treated with other oral hypoglycemic agents, repaglinide resulted in a 30% decrease in HbA1C, from 6.9% to 4.8%, with fasting and postprandial blood glucose levels decreased by 70 and 112mgdL_ 1, respectively. Repaglinide59 and nateglinide60 as combination therapy with metformin are more effective than either agent alone. Glitinides are taken before every meal but are not taken if a meal is skipped.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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