Clinical use

The thiazolidinediones are approved for use as monotherapy or in combination with secretagogues, metformin, or insulin therapy. Unlike most antidiabetic medications, which have a rapid onset of activity, pioglitazone and rosiglitazone require 8-12 weeks or more to achieve maximal clinical benefit. This is probably related to their mode of action, i.e., the regulation of gene expression. To date, there have been no head-to-head studies comparing rosiglitazone and pioglitazone, and no studies on patient characteristics that may predict a good treatment response with these agents.

When used as monotherapy or adjunctive therapy, thiazolidinediones typically decrease HbA1C by 1-1.5%.70 Clinical studies with rosiglitazone monotherapy lowered FPG by up to 55mgdL_ 1. Similarly, pioglitazone (15, 30, and 45 mg doses) reduced FPG (by 30, 32, and 56mgdL_ 1, respectively) and HbA1C (by 0.3, 0.3, and 0.9%, respectively).71 Dividing the daily dose (twice daily) was more effective in reducing both FPG levels and HbA1C levels compared with single daily dosing.72

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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