Clinical use

Metformin can be used as monotherapy or in combination with any other oral hypoglycemic agent. Metformin typically decreases HbA1C by 1-2%. The US Multicenter Metformin Study Group randomized individuals with T2DM who were inadequately controlled on diet alone to either metformin or placebo.64 After 6 months, the mean FPG was 189mgdL_ 1 (10.6mmolL_ 1) in the metformin group as compared with 244mgdL_ 1 (13.7mmolL_ 1) in the placebo group.

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