Figure 7 Continued and ATP (sulfonylurea receptor type 1 (SUR1)), and a K+ channel that acts as the pore-forming unit. Sulfonylurea binding and subsequent receptor activation leads to inhibition and closure of these K+-ATP channels. Inhibition of K+ channels induces b-cell membrane depolarization, opening voltage-dependent calcium channels and allowing calcium ion influx. The increase in intracellular calcium concentration leads to the fusion of insulin-containing secretory granules with

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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