Comparisons of rosiglitazone and pioglitazone

In vitro studies reveal that pioglitazone acts as a PPAR-g and partial PPAR-a agonist, whereas rosiglitazone is only a PPAR-g agonist. This difference may explain their different effects on lipid metabolism.73 Both rosiglitazone and pioglitazone improve HDL cholesterol levels by approximately 10%. Rosiglitazone is associated with an increase in LDL cholesterol concentration of 8-16%, which has not been seen with pioglitazone therapy. On the other hand, pioglitazone is associated with a decrease in triglyceride levels that has not been seen with rosiglitazone. Both agents decrease serum FFA concentrations by approximately 20-30%.

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