Conclusions

The adverse physiological, psychological, and economic effects of inadequate pain management have become increasingly recognized in recent years. This has been accompanied by a growing awareness on the part of patients and caregivers that pain need not be tolerated, and an increased emphasis amongst physicians on the proactive treatment of pain. The unmet need for new analgesics remains substantial. Recent advances in the neurobiology of pain, together with the development of new preclinical and clinical pain paradigms, have revealed new opportunities for the development of analgesics, and raised the exciting possibility of entirely novel classes of analgesics in the future.

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Prisca Honore, PhD, a native of France, received a doctoral degree in molecular pharmacochemistry and experimental pharmacology from the University of Paris. Her postdoctoral training was completed at the University of Minnesota in Minneapolis, where she studied the role of substance P receptors expressing spinal cord neurons in pain transmission using an SP-Saporin toxin, in addition to investigating the mechanisms underlying bone cancer pain. Prisca joined Abbott Laboratories in 2000 and is a senior group leader in the Neuroscience Research division, at Abbott Park, IL. In 2004, she received the John C. Liebeskind Early Career Scholar Award from the American Pain Society.

Biographies

Honore Prisca Abbott

Michael F Jarvis, PhD, received his doctoral training in behavioral neuroscience at Rutgers University. He is currently a project leader and associate research fellow in Neuroscience Research, at Abbott Laboratories. A continuing research interest has been the study of the role of purines in modulating nociceptive signaling. His current research is focused on the identification and characterization of novel analgesic drug targets and ligands.

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