Current and Targeted Medications

A current list of medications approved for the treatment of drug addiction is shown in Table 4. A brief description of these medications for treatment of specific drugs of abuse is described below. In all cases, new medications are under clinical and preclinical investigation. Examples of potential medications currently under clinical investigation are listed in Table 5 with their chemical structures being shown in Figure 8. As the mechanisms of actions of these agents are widely varied, no attempt to describe structure-activity relationships (SARs) within these classes of molecules has been made. However, the interested reader is referred to relevant review articles throughout the text that describe in more detail the drug design and synthesis of these agents.

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