Current Treatment

There are currently no drugs approved for use in the treatment of HD. The major clinical focus has been on management of the motor problems. However, in HD, there are a host of associated psychiatric conditions that include aggression, and irritability (~40% of cases), depression and suicide (~30% of cases), mania 10% of cases), apathy (b60% of cases), anxiety (~ 30% of cases, with a greater prevalence in men), obsessive-compulsive disorder (50%), and dementia. Anti-dopaminergic agents such as tetrabenazine 80 and DA receptor antagonists, including tiapride 81, pimozide 82, haloperidol 83, olanzapine 84, risperidone 85, and quetiapine 86,79'83 are used to treat chorea. Psychiatric conditions associated with HD are treated with amantadine 55, fluphenazine, SSRIs, and mirtazapine.79

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