Disease Models

Until the development of targeted drugs, most research was carried on the pylorus ligated rat, and the number and size of ulcers determined with administration of any chemical available. This strategy was totally unsuccessful, and was replaced, during the development of H2 receptor antagonists, by the measurement of acid secretion by the perfused rat stomach.14 Another model that proved useful in the measurement of the inhibition of acid secretion was the gastric fistula dog.15 With the arrival of the rabbit gastric gland preparation,16 for the first time a model became available for determining the effect of drugs on a mammalian model of acid secretion. When the H + /K+-ATPase became a target, isolated enzyme preparations proved useful.17

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