Disruptedin Schizophrenia 1 DISC1

Disrupted-in-schizophrenia 1 (DISC1) at chrlq is a component of the microtubule-associated dynein motor complex that is key to maintaining the centrosome complex and maintaining microtubular function. Depletion of endogenous DISC1 or mutated DISC1 causes neurite dysfunction in vitro and impairs cerebral cortex function in vivo, suggesting a neurodevelopmental role in schizophrenia.38 More recently, DISC1 has been found to interact with the UCR2 domain of the phosphodiesterase PDE4B, suggesting a possible role in cAMP signaling processes that may involve CREB (cAMP response element binding protein) elements.

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