Disruptedin Schizophrenia 1 DISC1

Disrupted-in-schizophrenia 1 (DISC1) at chrlq is a component of the microtubule-associated dynein motor complex that is key to maintaining the centrosome complex and maintaining microtubular function. Depletion of endogenous DISC1 or mutated DISC1 causes neurite dysfunction in vitro and impairs cerebral cortex function in vivo, suggesting a neurodevelopmental role in schizophrenia.38 More recently, DISC1 has been found to interact with the UCR2 domain of the phosphodiesterase PDE4B, suggesting a possible role in cAMP signaling processes that may involve CREB (cAMP response element binding protein) elements.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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