Diuretics are the most common initial treatment for mild hypertension (Figure 7). Based on their site of action in the kidneys, diuretics can be classified into loop, thiazide, and potassium-sparing diuretics. Loop or high-ceiling diuretics,

Treatment of hypertension and associated endothelial dysfunction

Current treatment

1. Diuretics

3. Vasodilators

4. ACE inhibitors

5. Angiotensin receptor blockers

6. Calcium channel blockers

Future treatment

1. L-Arginine supplements

2. Endothelin receptor blockers

3. EETs mimetics

4. sEH inhibitors

5. HETE inhibitors

6. Antioxidants

Figure 6 Current and future treatment of renal dysfunction and hypertension.

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