Experimental Disease Models

Recapitulating human disease pathophysiology in animals is a challenge, with many examples where activity in animal models has not been predictive of activity in human disease. This is especially true in the area of cognitive function where the actual tasks performed by animals differ substantially in terms of sophistication to those in humans. The complexity of the brain circuitry and the dominating brain regions differ widely, i.e., those distinguishing features separating humans from animals. Nonetheless, several models have been developed, which capture some, but not all, pathological features of AD and serve to provide systems in which to test mechanistic hypotheses.

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