Figure 11 Structures of key compounds leading to the discovery of rosuvastatin.

have not been reported, synthetic details have been described.70 In animal studies, pitavastatin also dose-dependently reduces total plasma cholesterol and LDLc, with concomitant reductions in serum TG.

Oral administration of pitavastatin (0.5mgkg_ 1 day_ 1) to hyperlipidemic rabbits for 26 weeks reduced total plasma cholesterol by 7-20% and also reduced the atherosclerotic lesion area. Pitavastatin is rapidly absorbed and has the highest overall bioavailability of any statin (~80%). Pitavastatin is also highly protein-bound (>95%). Like rosuvastatin and pravastatin, pitavastatin is not significantly metabolized by CYP3A4 enzymes, so the potential for drug-drug interactions is reduced. Pitavastatin is metabolized by CYP2C9 and CYP2C8. Pitavastatin has a reasonable duration of action and plasma half-life (t1/2 = 4-5 h). Pitavastatin 9 was launched in Japan in 2003 and is being tested clinically in the US.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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